Science of Tissue Generation

Natural tissue generation occurs when collagen structures are repopulated by host cells and supporting vasculature. To assist in the repair of tissue defects, physicians have enlisted both synthetic meshes and biologic “collagen scaffolds”, known as acellular dermal matrices (ADMs). These biologic scaffolds may be derived from human or other mammalian sources.

It is now beginning to be appreciated that the tissue repair’s source material as well as different tissue-processing methodologies produce post-implantation responses that differ significantly.

These can range from:

  • Non-incorporation
    • Encapsulation
    • Rejection
  • Incorporation
    • Resorption
    • Integration with progressive degradation
    • Adoption and adaptation

As a result of how we process our unique source material, SurgiMend ADMs are non-crosslinked, non-denatured collagen scaffolds that are free of preservatives, denatured proteins, artificial chemical crosslinks, cells, lipids, carbohydrates and other constituents, and come terminally sterilized. Upon implantation or application, they do not elicit an encapsulation or degradation response. The unique architecture of our devices provide ideal conditions for rapid revascularization while simultaneously allowing the device to persist, prolonging its impact in the repair process.

To better understand how a tissue’s source and its processing impact an ADM’s physicomechanical properties and host-implant interactions, review Extracellular Matrix Biomaterials for Soft Tissue Repair.